Education
M.D./PhD Xi’an Jiao Tong University, School of Medicine, P.R. China, 2001
MS, Xi’an Medical University, P.R. China, 1998
BS, Xi’an Medical University, P.R. China, 1995
Courses
2008-present Pharmacology lectures for Biomedical Sciences program; Co-coordinator
for Pharmacology for Biomedical Sciences
2010-present Pharmacology lectures for D.O. program
2013-present Biochemistry lectures for Biomedical Sciences program
Research
For the past decade, Dr. Chen's research has been conducted in topics related to the
cardiovascular system. Currently, she is interested in finding the key mechanisms
involved in various cardiovascular diseases, such as myocardial infarction, stroke
and diabetes. Vascular endothelial dysfunction and inflammation are two critical events
initiating the pathogenesis of these diseases, and in her lab multiple animal models
and biochemical techniques are combined to evaluate blood vessel biochemical properties
(e.g., blood nitric oxide and hydrogen peroxide) in real-time, organ blood perfusion,
and inflammation (i.e., leukocyte-endothelial interactions). Her research will clarify
the roles of endothelial nitric oxide synthase, NADPH oxidase, damaged mitochondria,
and key enzyme regulations and signaling pathways, which will provide new treatment
strategies for cardiovascular diseases.
Research Keywords
Vascular endothelial dysfunction
Leukocyte-endothelial interactions
Hyperglycemia
Myocardial ischemia/reperfusion injury
Inflammation
Oxidative stress
Endothelial nitric oxide synthase
Hydrogen peroxide
Nitric oxide
Memberships
2005-2014 Neuroscience Society, Regular Member
2007-present Sigma Xi Society, Regular Member
2011-present American Peptide Society, Regular Member
2013-present American Heart Association, Regular Member
Grants
Center for Chronic Disorders of Aging (CCDA) at PCOM (07/01/2013-06/30/2014)
Title: The role of mitochondria in acute hyperglycemia: activation of vascular NADPH
oxidase and eNOS uncoupling
Role on Project: PI
Pennsylvania State Tobacco Grant (grant #4100057680) 01/01/2012-12/31/2015
Title: “Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury
tissues”
Role on Project: Co-investigator
Other
Volunteer and Leadership Activities
- Reviewer: Evidence-Based Complementary and Alternative Medicine